Human LMBR1 (NP_071903.2) VersaClone cDNA

Name: Human LMBR1 (NP_071903.2) VersaClone cDNA
Brand: R&D Systems
SKU: RDC3556
Price: 250 USD
Availability: InStock

R&D Systems | Catalog # RDC3556

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Background
Product Documents
Specific Notices

Key Product Details

Species

Human

Accession Number

NP_071903.2

Background: LMBR1

Shh (Sonic Hedgehog) is expressed in embryonic tissues that are critical for the patterning of the developing central nervous system, somite, and limb. It is also involved in whisker, hair, foregut, tooth, and bone development. Shh regulates neural and hematopoietic stem cell fate and is important for thymocyte differentiation and proliferation. In adult tissue Shh is associated with cancer development and tissue remodeling following injury. Palmitoylation and cholesterol addition of Shh contribute to its membrane tethering and assembly into multimers. Lipid modification and multimerization greatly increase Shh signaling potency. Shh can be released from the plasma membrane by the cooperative action of DISP1, SCUBE2, and TACE/ADAM17. Canonical signaling of Shh is mediated by a receptor complex that includes Patched (PTCH1, PTCH2) and Smoothened (SMO).

Long Name

Limb Development Membrane Protein 1

Alternate Names

ACHP, C7orf2, DIF14, PPD2, THYP, ZRS

Entrez Gene IDs

64327 (Human)

Gene Symbol

LMBR1

UniProt

NP_071903.2 (Human)

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Product Specific Notices for Human LMBR1 (NP_071903.2) VersaClone cDNA

For research use only

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