Human MAD1L1 Alexa Fluor® 700-conjugated Antibody

Catalog #: AF4194N Datasheet / COA / SDS

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AF4194N-100UG

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Human MAD1L1 Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human MAD1L1 in Western blots.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human MAD1L1
Met1-Asp350
Accession # Q9Y6D9

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: MAD1L1

MAD1L1 (mitotic arrest deficient 1-like 1) is a member of the spindle-assembly checkpoint (SAC) which prevents anaphase from occurring until all chromosomes are properly aligned at the metaphase plate. Upon checkpoint activation, MAD1L1 recruits MAD2 to unattached kinetochores, promoting the binding of MAD2 to CDC20, the activator for the anaphase-promoting complex. MAD1L1 has been implicated to have tumor-suppressing functions, but in small-cell lung cancer cell lines, the MAD1L1 gene is the most frequent copy number gain, suggesting a more complex role.

Long Name

MAD1 Mitotic Arrest Deficient-Like 1

Entrez Gene IDs

8379 (Human); 17120 (Mouse); 680006 (Rat)

Alternate Names

hMAD1; HsMAD1; MAD1 mitotic arrest deficient-like 1 (yeast); MAD1; MAD1L1; MAD1-like protein 1; MAD1yeast, homolog-like 1; Mitotic checkpoint MAD1 protein homolog; PIG9; Tax-binding protein 181; TP53I9; tumor protein p53 inducible protein 9; TXBP181; TXBP181MAD1 (mitotic arrest deficient, yeast, homolog)-like 1