Human MIG2 Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB6984S Datasheet / COA / SDS

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FAB6984S-100UG

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Human MIG2 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human MIG2 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) MIG, rhFERMT1 (aa 514‑677), rhMIG2/FERMT2 (aa 514‑680), or rhFERMT3 (498‑667) is observed.

Source

Monoclonal Mouse IgG2b Clone # 696906

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human MIG2
Gln321-Leu444
Accession # Q96AC1

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: MIG2

MIG2 (mitogen-inducible gene-2), also known as FERMT2 or Kindlin-2, is an approximately 80 kDa, 680 amino acid (aa), ubiquitously expressed member of the Fermitin/Kindlin family of cytoplasmic adaptor proteins. MIG2 is essential for beta 1 and beta 3 integrin activity due to its interactions with regulatory molecules such as talin and ILK. MIG2 contains two FERM domains (aa 285-326 and aa 524-573) and one pleckstrin homology domain (aa 373-478). Within the region used as an immunogen, human MIG2 shares 98% aa identity with mouse and rat MIG2. Two isoforms (687 aa and 633 aa) have a 7 aa insert after aa 534. The shorter isoform also has a 2 aa substitution for the C-terminal 57 aa of the 680 aa form.

Long Name

Mitogen Inducible Gene 2

Entrez Gene IDs

10979 (Human); 218952 (Mouse); 289992 (Rat)

Alternate Names

fermitin family homolog 2 (Drosophila); fermitin family homolog 2; fermitin family member 2; FERMT2; KIND2; KIND2DKFZp686G11125; kindlin 2; Kindlin-2; MIG2; mig-2; MIG2FLJ34213; mitogen inducible gene 2 protein; Mitogen-inducible gene 2 protein; PH domain-containing family C member 1; pleckstrin homology domain containing, family C (with FERM domain) member 1; pleckstrin homology domain containing, family C member 1; Pleckstrin homology domain-containing family C member 1; PLEKHC1; PLEKHC1FLJ44462; UNC112; UNC112B