Human/Mouse IRF2 Alexa Fluor® 532-conjugated Antibody

Catalog #: AF4529X Datasheet / COA / SDS

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AF4529X-100UG

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Human/Mouse IRF2 Alexa Fluor® 532-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects endogenous human and mouse IRF2 in Western blots.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant mouse IRF2
Val151-Cys349
Accession # P23906

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 532 (Excitation= 534 nm, Emission= 553 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: IRF2

Interferon Regulatory Factor 2 (IRF2) belongs to the interferon regulatory transcription factor family. IRF2 functions as a regulator of type I interferons by influencing cellular proliferation and immune response through transcriptional regulation. IRF2 competitively inhibits IRF1 gene activation, as well as, stimulating transcription on its own. Overexpression of IRF2 in NIH3T3 cells leads to transformation, whereas, loss of IRF2 expression in knock out mice leads to a variety of abnormalities including loss of NK cells due to increased apoptosis.

Long Name

Interferon Regulatory Factor 2

Entrez Gene IDs

3660 (Human); 16363 (Mouse); 290749 (Rat)

Alternate Names

DKFZp686F0244; interferon regulatory factor 2; IRF2; IRF-2