Human/Mouse LPP Alexa Fluor® 594-conjugated Antibody

Catalog #: FAB6927T Datasheet / COA / SDS

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FAB6927T-100UG

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Human/Mouse LPP Alexa Fluor® 594-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human LPP in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human TRIP-4, -6, or -11 is observed.

Source

Monoclonal Mouse IgG2b Clone # 691121

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human LPP
Lys138-Gln261
Accession # Q93052

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 594 (Excitation= 590 nm, Emission= 617 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: LPP

Human LIM domain-containing preferred translocation partner in lipoma (LPP) is an 80 kDa intracellular protein that contains an N-terminal Pro-rich region (aa 41-370) followed by three tandem LIM domains (aa 414-603). It localizes to focal adhesion plaques where it regulates junction assembly and cytoskeleton remodeling through interactions with a-Actinin, VASP, SCRIB, Supervillin, and Palladin. In the nucleus, LPP coactivates the transcription factor PEA3 and protects telomeres from DNA damage. LPP is a frequent target of chromosomal translocations with HMG-A2 in lipoma. Within aa 138-261, human LPP shares 90% and 77% aa sequence identity with mouse and rat LPP, respectively.

Long Name

Lipoma-Preferred Partner

Entrez Gene IDs

4026 (Human); 210126 (Mouse); 288010 (Rat)

Alternate Names

DKFZp779O0231; FLJ30652; FLJ41512; LIM domain containing preferred translocation partner in lipoma; LIM domain-containing preferred translocation partner in lipoma; LIM protein; lipoma-preferred partner; LPP