Human/Mouse Preso/FRMPD4 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB7676V Datasheet / COA / SDS

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FAB7676V-100UG

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All Preso/FRMPD4 Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse Preso/FRMPD4 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human Preso/FRMPD4 in direct ELISAs and human and mouse Preso/FRMPD4 in Western blots.

Source

Monoclonal Mouse IgG2b Clone # 809408

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Preso/FRMPD4
Asn890-Ser1022
Accession # Q14CM0

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Preso/FRMPD4

Preso, also known as FRMPD4 and PDZD10, is a scaffolding protein that is widely expressed in the brain as 140 kDa and 170 kDa species. It contains one WW domain (aa 33-66) one PDZ domain (aa 78-155), and one FERM domain (aa 204-519). The 140 kDa species is enriched in post-synaptic densities where it interacts with PSD-95, SAP97, SAP102, and F-actin. Preso promotes dendritic spine extension and maintenance as well as excitatory synaptic transmission. Within aa 890-1022, human Preso shares approximately 94% aa sequence identity with mouse and rat Preso.

Long Name

FERM and PDZ Domain Containing 4

Entrez Gene IDs

9758 (Human); 333605 (Mouse); 302656 (Rat)

Alternate Names

FERM and PDZ domain containing 4; FERM and PDZ domain-containing protein 4; FRMPD4; MGC142260; MGC142262; PDZ domain containing 10; PDZD10; PDZK10; Preso