PRMT/PRMT1 (Protein-Arginine Methyltransferase 1; also HRMT1L2 and HMT2) is a 42‑45 kDa type I member of the arginine N‑methyltransferase family of enzymes. It is ubiquitously expressed and dimethylates single arginine residue nitrogen atoms in a distributive manner (i.e.-with substrate release following each methlyation step). PRMT1 forms homodimers, and heterodimers with PRMT3, and exists as part of a 300‑400 kDa complex in vivo. Human PRMT1 is 361 amino acids in length and contains one adenosyl-L-methionine binding site (aa 85‑153) and a phosphorylation site at Tyr299. There are multiple splice variants that show distinct substrate specificities. There is an alternate start site 10 aa upstream of the standard start site, and a single Met, plus a five aa and 11 aa substiuition for aa 1‑19. One isoform has a 2 aa substitution for aa 1‑20 accompanied by a deketion of aa 52‑67. Over aa 218‑361, human PRMT1 is 100% identical in aa sequence to mouse PRMT1.
Human/Mouse PRMT1 Alexa Fluor™ Plus 488‑conjugated Antibody
R&D Systems | Catalog # AF6016AFP488
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
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Isotype
Applications for Human/Mouse PRMT1 Alexa Fluor™ Plus 488‑conjugated Antibody
Western Blot
Formulation, Preparation, and Storage
Formulation
Shipping
Stability & Storage
Background: PRMT1
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UniProt
Additional PRMT1 Products
Product Documents for Human/Mouse PRMT1 Alexa Fluor™ Plus 488‑conjugated Antibody
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Product Specific Notices for Human/Mouse PRMT1 Alexa Fluor™ Plus 488‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
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