Human/Mouse/Rat DYRK3 Alexa Fluor® 488-conjugated Antibody

Catalog #: FAB5409G Datasheet / COA / SDS

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FAB5409G-100UG

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Human/Mouse/Rat DYRK3 Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human, mouse, and rat DYRK3 in Western blots.

Source

Monoclonal Mouse IgG1 Clone # 563518

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human DYRK3
Asn52-Glu167
Accession # O43781

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: DYRK3

DYRK3 (Dual-specificity tyrosine [Y] phosphorylation regulated kinase 3; also REDK) is a 70‑72 kDa member of the MNB/DYRK subfamily, CMGC Ser/Thr protein kinase family of enzymes. It is expressed in testis and erythroid-lineage precursors, and shows dual substrate specificity; autophosphorylation on Tyr369 to self‑activate, and a Ser/Thr phosphorylation of target molecules. Substrates include CREB and Histone 2B. Human DYRK3 is 588 amino acids (aa) in length and contains one kinase catalytic domain (aa 209‑522). There are two potential isoform variants that show either a six aa substitution for aa 1‑26, or this same substitution in combination with a premature truncation after Gln263. DYRK3 immunoreactive proteolysis bands of 30 and 40 kDa have been detected in DYRK3-transfected cells. Over aa 52‑167, human DYRK3 shares 75% aa identity with mouse DYRK3.

Long Name

Dual-specificity Tyrosine-[Y]-phosphorylation Regulated Kinase 3

Entrez Gene IDs

8444 (Human); 226419 (Mouse); 304775 (Rat)

Alternate Names

dual specificity tyrosine-phosphorylation-regulated kinase 3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5; DYRK3; DYRK5; EC 2.7.12; EC 2.7.12.1; hYAK3-2; protein kinase Dyrk3; REDK; REDKRED; Regulatory erythroid kinase; YAK3-2