Human/Mouse/Rat HSPB8 Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB4987N Datasheet / COA / SDS

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FAB4987N-100UG

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Human/Mouse/Rat HSPB8 Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human, mouse, and rat HSPB8 in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG1 Clone # 520817

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human HSPB8
Ala2-Thr196
Accession # Q9UJY1

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: HSPB8

Heat shock protein beta-8 (HSPB8, also HSP22 or CRYAC) is a 22‑25 kDa member of the small HSP (HSP20) family of proteins. It is expressed in muscle (smooth, skeletal and cardiac), and serves as a molecular chaperone. Human HSPB8 contains one alpha -crystalline domain (aa 93‑170) that mediates protein-protein interaction, and N- plus C-terminal flanking sequences that generate homodimers, homooligomers, and heterodimers with HSP27 and HSPB7. Phosphorylation at Ser57 blocks HSPB8 chaperone activity. Human HSPB8 shares 94% aa identity with both mouse and canine HSPB8. Deficiencies in HSPB8 are involved in distal motor neuropathy type 11A.

Long Name

Heat Shock Protein beta 8

Entrez Gene IDs

26353 (Human); 80888 (Mouse); 113906 (Rat)

Alternate Names

Alpha-crystallin C chain; CMT2L; CRYAC; DHMN2; E2IG1; E2IG1E2-induced gene 1 protein; H11; H11DHMN2; heat shock 22kDa protein 8; heat shock 27kDa protein 8; heat shock protein beta-8; HMN2; HMN2A; HSP22; HSP22CMT2L; HSPB8; Protein kinase H11; Small stress protein-like protein HSP22