Human/Mouse/Rat IMPA1/IMP1 Alexa Fluor® 594-conjugated Antibody

Catalog #: FAB98901T Datasheet / COA / SDS

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FAB98901T-100UG

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All IMPA1/IMP1 Antibodies

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Human/Mouse/Rat IMPA1/IMP1 Alexa Fluor® 594-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human IMPA/IMPA1 Peptide in direct ELISAs. Detects human, mouse, and rat IMPA/IMPA1 in Western blots.

Source

Monoclonal Mouse IgG2b Clone # 984603

Purification

Protein A or G purified

Immunogen

Synthetic peptide containing human IMPA/IMPA1 Peptide
Accession # P29218

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 594 (Excitation= 590 nm, Emission= 617 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: IMPA1/IMP1

IMPA-1/inositol(myo)-1(or 4)-monophosphatase 1 is a ubiquitous enzyme with broad specificity, which is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. IMPA-1 dephosphorylates myo-inositol monophosphatate to modulate intracellular signal transduction. IMPA-1 forms homodimers, and is abundantly expressed in brain. The magnesium-dependent phosphatase activity is inhibited by lithium, thereby depressing myo-inositol production, which may explain the anti-depressive and anti-manic effects of lithium therapy in bipolar disorder.

Long Name

Inositol Monophosphatase 1

Entrez Gene IDs

3612 (Human); 55980 (Mouse); 83523 (Rat)

Alternate Names

EC 3.1.3.25; IMP 1; IMP; IMP1; IMPA; IMPA1; IMPase 1; inositol monophosphatase 1; inositol(myo)-1(or 4)-monophosphatase 1; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; MRT59; Myo-Inositol Monophosphatase 1