Human/Mouse/Rat Inosine 5'-Monophosphate Dehydrogenase 2/IMPDH2 Alexa Fluor® 532-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: IMP Dehydrogenase 2/IMPDH2

IMP Dehydrogenase 2 (IMPDH2), also known as type II Inosine 5'-Monophosphate Dehydrogenase and IMPD2, is the rate-limiting enzyme in de novo guanine nucleotide biosynthesis. Along with closely related enzyme IMPDH1, IMPDH2 catalyzes the conversion of Inosine 5’-Phosphate (IMP) to Xanthosine 5’-Phosphate (XMP), and is responsible for maintaining the cellular guanine deoxy- and ribonucleotide pools required for DNA and RNA synthesis, respectively. IMPDH2 regulation is associated with cellular proliferation, transformation and differentiation, and its levels are selectively upregulated in neoplastic and replicating cells. Therefore, it has been evaluated as a target for anti-tumor, anti-infective and immunosuppressive drugs.  Human IMPDH2 is a 56 kDa protein that shares 84% amino acid (aa) identity with human IMPDH1, and 98% aa identity with mouse and rat IMPDH2.

Product Datasheets

Related Research Areas

• Additional Reduction/Oxidation (Redox) Enzymes
• Dehydrogenases/Reductases
• Redox Enzymes