Human/Mouse/Rat T Cell Receptor alpha  Chain-V  alpha 24-J  alpha Q Alexa Fluor® 647-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: T Cell Receptor alpha Chain-V alpha 24-J alpha Q

V alpha 24-J alpha Q (T cell receptor alpha chain) is a 31 kDa (predicted) member of the Ig superfamily. It constitutes an invariant alpha -chain that is paired with the V beta 11 chain on human NKT^INV cells, a subpopulation of NKR-P1A T cells. This TCR creates a binding site for CD1d-associated ligands that are presumed to involve glyco‑/phospholipids. The human V alpha 24V beta 11 TCR is analogous to the V alpha 14V beta 8 complex in mice. Human V alpha 24-J alpha Q is 276 amino acids in length. It contains a 21 aa signal sequence, multiple N-linked glycosylation sites, a V-type Ig-like domain (aa 36‑133) and a TCR-related sequence of unknown function (aa 142‑255). Considerable variability is noted over aa 22‑114. The closest mouse ortholog to human V alpha 24-J alpha Q shows 65% aa identity over aa 22‑135.

Product Datasheets

Related Research Areas

• T Cell Antigen Recognition