Human/Mouse RND3 (RD1 Peptide) Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB6618N Datasheet / COA / SDS

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FAB6618N-100UG

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Human/Mouse RND3 (RD1 Peptide) Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human RND3 in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG1 Clone # 687202

Purification

Protein A or G purified

Immunogen

RND3 (RD1 peptide)
Cys197-Arg207
Accession # P61587

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: RND3

RND3, also known as RhoE, is an approximately 27 kDa member of the Rho family, small GTPase superfamily of molecules. It is 244 amino acids (aa) in length, and the mature chain extends from aa 1-241. RND3 is ubiquitously expressed and is involved in keratinocyte differentiation and stratification. RND3 overexpression results in cell size enlargement and an increase in the number of stratified cells. RND3 depletion results in hyperproliferation and delays initiation of keratinocyte differentiation. Human RND3 shares 100% aa sequence identity with mouse RND3.

Long Name

Rho family GTPase 3

Entrez Gene IDs

390 (Human)

Alternate Names

ARHE; MemB; Protein MemB; Rho family GTPase 3member E; Rho8; RHOE; Rho-related GTP-binding protein Rho8; rho-related GTP-binding protein RhoE; RND3; small GTP binding protein Rho8