Human/Mouse SATB1 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB8075R Datasheet / COA / SDS

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FAB8075R-100UG

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Human/Mouse SATB1 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human and mouse SATB1 in ELISAs and Western blots.

Source

Monoclonal Mouse IgG2b Clone # 815427

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human SATB1
Met1-Ser260
Accession # Q01826

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: SATB1

SATB1 (special AT-rich sequence binding protein-1) is an approximately 103 kDa nuclear matrix-associated homeobox transcription factor that binds AT rich DNA sequences at scaffolding protein attachment and viral genome integration sites. It is a key factor integrating higher-order chromatin architecture with gene regulation. Specifically, it is involved in MHC class-I gene organization and chromatin organization in undifferentiated thymocytes. SATB1 is cleaved into 65-70 kDa and 25‑30 kDa fragments during apoptosis. Human SATB1 shares 99% amino acid sequence identity with mouse and rat SATB1.

Long Name

SATB Homeobox 1

Entrez Gene IDs

6304 (Human); 20230 (Mouse); 316164 (Rat)

Alternate Names

DNA-binding protein SATB1; SATB homeobox 1; SATB1; special AT-rich sequence binding protein 1 (binds to nuclearmatrix/scaffold-associating DNA's); Special AT-rich sequence-binding protein 1