Human/Mouse SOCS-4 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB5628R Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
FAB5628R-100UG

Save 15% on Select RUO Reagents. See Details.

All SOCS-4 Antibodies

Product Details

Supplemental Products

Reviews

Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse SOCS-4 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects endogenous human and mouse SOCS-4 in Western blots.

Source

Monoclonal Mouse IgG2b Clone # 517331

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human SOCS-4
Met1-Cys440
Accession # Q8WXH5

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: SOCS-4

Suppressor of cytokine signaling 4 (SOCS-4) is a 51 kDa (predicted) member of the SOCS family of proteins, which are Src homology-2 (SH2)-containing proteins originally identified as negative regulators of cytokine signaling. Human SOCS-4 is 440 amino acids (aa) in length. It contains an SH2 domain (aa 289‑381) and a SOCS box domain (aa 376‑425). Human SOCS-4 shares 93% and 86% aa sequence identity with bovine and mouse SOCS-4, respectively. The biological function of SOCS-4 remains poorly understood, but it has been found to be elevated in cells following treatment with EGF, acting perhaps in a feedback loop inhibiting STAT3.

Long Name

Suppressor Of Cytokine Signaling 4

Entrez Gene IDs

122809 (Human); 67296 (Mouse); 305828 (Rat)

Alternate Names

CIS4; DKFZp686J1568; SOCS4; SOCS-4; SOCS7; SOCS-7; SSI4; STAT4; suppressor of cytokine signaling 4; Suppressor of cytokine signaling 7SH2 domain containing SOCS box protein