Human/Mouse Sulfatase-2/SULF2 Alexa Fluor® 750-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Sulfatase-2/SULF2

Sulfatase 2 (SULF2) is a 132 kDa calcium-binding glycoprotein that is one of two extracellular sulfatases (SULFs). SULFs degrade cell surface and extracellular matrix heparin sulfate proteoglycans, altering the binding and signaling of factors such as Wnts and FGFs. Dysregulation of SULF2 is implicated in carcinogenesis. A high molecular weight form (250 kDa) is presumed to be a covalent dimer, while smaller forms (60 kDa and 64 kDa) are produced by proteolytic cleavage. A splicing form, isoform b, differs only in non-coding regions. Within the region used as an immunogen, human SULF2 shares approximately 94% amino acid sequence identity with mouse and rat SULF2, while mouse and rat SULF2 share 98% amino acid sequence identity with each other.

Product Datasheets

Related Research Areas

• Glycobiology-related Enzymes
• Lysosomal Enzymes
• Proteoglycan Regulators
• Search Glycobiology-related Enzymes
• Sulfation Regulators