Human MSP beta Chain Alexa Fluor® 532-conjugated Antibody

Catalog #: FAB735X Datasheet / COA / SDS

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FAB735X-100UG

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Human MSP beta Chain Alexa Fluor® 532-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects recombinant human (rh)MSP beta chain in direct ELISAs and Western blots. Shows no cross-reactivity with rhMSP alpha chain.

Source

Monoclonal Mouse IgG2b Clone # 68801

Purification

Protein A or G purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human MSP Î² chain
Val484-Gly711
Accession # P26927

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 532 (Excitation= 534 nm, Emission= 553 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Blockade of Receptor-ligand Interaction

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: MSP/MST1

MSP, also known as hepatocyte growth factor-like protein (HGFl), and scatter factor-2 (SF2), is a member of the HGF family of growth factors. It is secreted as a single chain inactive precursor which is proteolytically activated to yield a biologically active disulfide-linked heterodimer of the alpha and beta chains. MSP induces keratinocyte proliferation, bone resorption, and cell migration and shape change in resident macrophages. Heterodimeric MSP binds to and activates the cell surface receptor tyrosine kinase, RON/STK, which is expressed on mature macrophages, keratinocytes, and vascular endothelium of wounded skin.

Long Name

Macrophage Stimulating Protein/Macrophage Stimulating 1 [Hepatocyte Growth Factor-like]

Entrez Gene IDs

4485 (Human); 15235 (Mouse); 24566 (Rat)

Alternate Names

D3F15S2; EC 3.4.21; hepatocyte growth factor-like protein homolog; HGFL; HGFLhepatocyte growth factor-like protein; macrophage stimulating 1 (hepatocyte growth factor-like); Macrophage stimulatory protein; Macrophage-stimulating protein; MSP; MSPDNF15S2; MST1; NF15S2; SF2