NALP3 (NAcht Leucine-rich repeat Protein 3), also known as CIAS1, PYPAF or Cryopyrin is a cytosolic ~120 kDa member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NALP3 activates caspases 1 and 5. Defects in NALP3 may cause FCAS1, CINCA, or Muckle-Wells autoinflammatory syndromes.
Human NLRP3/NALP3 (NP_004886.3) VersaClone cDNA
R&D Systems | Catalog # RDC3035
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: NLRP3/NALP3
Long Name
NLR Family, Pyrin Domain Containing 2
Alternate Names
AGTAVPRL, AII, CIAS1, Cryopyrin, FCAS, FCU, MWS, NACHT, NALP3, PYPAF1
Gene Symbol
NLRP3
UniProt
Additional NLRP3/NALP3 Products
Product Documents for Human NLRP3/NALP3 (NP_004886.3) VersaClone cDNA
Product Specific Notices for Human NLRP3/NALP3 (NP_004886.3) VersaClone cDNA
For research use only
Related Research Areas
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Associated Pathways
NOD-like Receptor Signaling Pathways
