PI16 (Peptidase Inhibitor 16; also PSP94-binding protein) is a 70‑75 kDa member of the CRISP family of proteins. It is expressed by prostatic fibroblasts and cardiomyocytes and is known to bind PSP94. The human PI16 precursor is 463 amino acids (aa) in length. It contains a 27 aa signal peptide plus a 436 aa mature region. The mature region has been described as being either a type I transmembrane (TM) glycoprotein with a TM segment between aa 443‑462, or a GPI‑linked glycoprotein with C‑terminal cleavage between Lys437‑Asn438. Three potential variants exist. One shows a deletion of aa 231‑423, a second shows a 9 aa substitution for the C‑terminal 64 aa and a third shows a 43 aa insertion after Cys197. Over aa 28‑437, human PI16 is 67% aa identical to mouse PI16.
Human Peptidase Inhibitor 16/PI16 Alexa Fluor™ Plus 488‑conjugated Antibody
R&D Systems | Catalog # AF4980AFP488
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Background: Peptidase Inhibitor 16/PI16
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This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
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