Human PP4 Catalytic Subunit Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB5074N Datasheet / COA / SDS

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FAB5074N-100UG

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Human PP4 Catalytic Subunit Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human, mouse, and rat PP4 Catalytic Subunit in Western blots.

Source

Monoclonal Mouse IgG2b Clone # 501517

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human PP4 Catalytic Subunit
Met1-Leu307
Accession # P60510

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PP4

The catalytic subunit of Protein Phosphatase 4 (PP4), also called PPX, is a serine/threonine protein phosphatase with about 65% homology to PP2A. Although PP4 has the same heterotrimeric subunit structure as PP2A and can use many of the PP2A regulatory subunits, PP4 also has its own unique scaffolding and regulatory subunits. PP4 is largely found in the centrosome of the nucleus where it may play a role in modulating transcription factor phosphorylation by JNK. In Drosophila, cmm mutants have low levels of PP4 and are unable to complete mitosis due to a deficit in microtubule assembly.

Long Name

Protein Phosphatase 4

Entrez Gene IDs

5531 (Human); 56420 (Mouse); 171366 (Rat)

Alternate Names

EC 3.1.3.16; PP4; PP4C; PP4protein phosphatase X, catalytic subunit; PPH3; PPP4C; PPX; PP-X; PPXPPH3; protein phosphatase 4 (formerly X), catalytic subunit; protein phosphatase 4, catalytic subunit; Protein phosphatase X