Human PTP rho/PTPRT Alexa Fluor® 532-conjugated Antibody

Catalog #: AF3697X Datasheet / COA / SDS

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AF3697X-100UG

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Human PTP rho/PTPRT Alexa Fluor® 532-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human PTPρ/PTPRT in Western blots. In Western blots, no cross-reactivity with recombinant human LAR, PTPRM, K, S, G or DEP1/CD148 is observed.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human PTPÏ/PTPRT
Gln26-Lys725
Accession # O14522

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 532 (Excitation= 534 nm, Emission= 553 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PTP rho/PTPRT

Protein Tyrosine Phosphatase, Receptor-type T (PTPRT), also known as RPTPrho, dephosphorylates tyrosine residues in proteins. PTPRT is present in many tissues, including brain, heart, lung, and colon. Genetic screening of colon cancers indicates that the PTPRT gene has a high incidence of missense mutations that reduce phosphatase activity in the encoded protein. Overexpression of intact PTPRT in cancer cell lines inhibits cell proliferation, suggesting that the phosphatase is a tumor suppressor.

Long Name

Protein Tyrosine Phosphatase Receptor-type T

Entrez Gene IDs

11122 (Human); 19281 (Mouse); 362263 (Rat)

Alternate Names

EC 3.1.3; EC 3.1.3.48; KIAA0283RPTPrho; protein tyrosine phosphatase, receptor type, T; PTP rho; PTPRT; receptor protein tyrosine phosphatase; Receptor-type tyrosine-protein phosphatase rho; receptor-type tyrosine-protein phosphatase T; RPTP-rho; R-PTP-T