Human/Rat PTPπ/PTPRU Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB7475U Datasheet / COA / SDS

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FAB7475U-100UG

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All PTP pi/PTPRU Antibodies

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Human/Rat PTPπ/PTPRU Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human, Rat

Specificity

Detects human and rat PTPπ/PTPRU in Western blots and recombinant human PTPRU in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) PTPRK, rhPTPRM, or rhPTPRT is observed.

Source

Monoclonal Mouse IgG1 Clone # 764209

Purification

Protein A or G purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human PTPÏ€/PTPRU
Glu19-Gln740
Accession # Q92729

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PTP pi/PTPRU

Protein Tyrosine Phosphatase, receptor type U (PTPRU), also called PCP-2 or PTPp, is an approximately 180 kDa type I transmembrane glycoprotein that is a type IIb receptor-like protein tyrosine phosphatase (PTPR). The 731 amino acid (aa) extracellular domain contains MAM, Ig-like C-type and Fibronectin III domains that often mediate cell adhesion, but unlike other family members, PTPRU does not appear to mediate homophilic cell aggregation. It does, however, antagonize Wnt signaling in adherens junctions by inhibiting beta -catenin-mediated gene transcription. Human PTPRU shares 95% aa sequence identity with mouse and rat PTPRU within the extracellular domain, and up to 60% aa identity with other human family members. Isoforms of 1436, 1440 and 1433 aa are altered within the cytoplasmic domain as compared to the 1446 aa full-length form. Several tissues contain detectable amounts of PTPRU mRNA.

Long Name

Receptor-type Protein Tyrosine Phosphatase pi

Entrez Gene IDs

10076 (Human); 19273 (Mouse); 116680 (Rat)

Alternate Names

FMI; GLEPP1; hPTP-J; pancreatic carcinoma phosphatase 2; PCP2; PCP-2; pi R-PTP-Psi; protein tyrosine phosphatase J; protein tyrosine phosphatase, receptor type, U; protein-tyrosine phosphatase J; protein-tyrosine phosphatase pi; PTP pi; PTP; PTP-J; PTP-PI; PTPPSI; PTPRO; PTP-RO; PTPRU; Receptor protein tyrosine phosphatase hPTP-J; R-PTP-PSI; R-PTP-U