Human SGK3 (NP_037389.4) VersaClone cDNA

Name: Human SGK3 (NP_037389.4) VersaClone cDNA
Brand: R&D Systems
SKU: RDC3561
Price: 250 USD
Availability: InStock

R&D Systems | Catalog # RDC3561

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Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Human

Accession Number

NP_037389.4

Background: SGK3

SGKL/SGK3, also known as CISK for cytokine-independent survival kinase, is a SGK type protein kinase. The protein contains a lipid-binding phox homology (PX) domain, which is required for targeting SGKL/SGK3 protein to the endosomal compartment. SGKL/SGK3 functions downstream of the phosphoinositide 3-kinase (PI3K) cascade and has been implicated in cell survival. The protein has been shown to be phosphorylated and activated by 3-phosphoinositide-dependent protein kinase 1 (PDK1), and to a lesser extent insulin-like growth factor-1, in vitro. Activated SGKL/SGK3 has been shown to phosphorylate glycogen synthase kinase 3 beta (GSK-3beta) in vitro. SGKL/SGK3 expression has been documented in many human tissues but was found to be most abundant in lung. ESTs have been isolated from human tissue libraries, including normal liver, breast and thyroid and cancerous spleen, ear and pancreas.

Long Name

Serum/Glucocorticoid Regulated Kinase 3

Alternate Names

CISK

Entrez Gene IDs

23678 (Human)

Gene Symbol

SGK3

UniProt

NP_037389.4

Additional SGK3 Products

Product Documents for Human SGK3 (NP_037389.4) VersaClone cDNA

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Product Specific Notices for Human SGK3 (NP_037389.4) VersaClone cDNA

For research use only

Related Research Areas

Cancer Biomarkers

Ion Channels and Regulators

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