Human SOX18 Alexa Fluor® 700-conjugated Antibody

Catalog #: AF5077N Datasheet / COA / SDS

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AF5077N-100UG

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Human SOX18 Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects endogenous human SOX18 in Western blots.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human SOX18
Ala276-Gly384
Accession # P35713

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: SOX18

SOX18 (SRY-related HMG box) is a 41 kDa (predicted) Group F member of the SOX family of DNA-binding proteins. Human SOX18 is 384 amino acids (aa) in length and contains an N-terminal DNA-binding HMG box (aa 85‑153), a central TAD region (aa 168‑260) and a highly charged sequence that contains a nine aa transactivation motif (aa 323‑331). SOX18 is expressed by endothelium and vascular smooth muscle, and apparently promotes the formation and organization of new capillaries. Over aa 276‑384, human SOX18 shares 90% and 89% aa identity with mouse and porcine SOX18, respectively.

Long Name

SRY-related HMG-box 18

Entrez Gene IDs

54345 (Human); 20672 (Mouse); 311723 (Rat)

Alternate Names

HLTS; SOX18; SRY (sex determining region Y)-box 18; SRY-box 18; transcription factor SOX-18