Human TACC3 Alexa Fluor® 532-conjugated Antibody

Catalog #: AF5720X Datasheet / COA / SDS

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AF5720X-100UG

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Human TACC3 Alexa Fluor® 532-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human TACC3 in Western blots.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human TACC3
Glu689-Ile838
Accession # Q9Y6A5

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 532 (Excitation= 534 nm, Emission= 553 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: TACC3

Transforming acidic coiled-coil containing protein 3 (TACC3; also know as ERIC-1) is a 92‑140 kDa member of the TACC family of transcriptional regulatory proteins. It is expressed in a variety of cell types, including Sertoli cells, endothelial cells, erythroid progenitors, and thyroid epithelium. When phosphorylated by Aurora A on Ser558, it stabilizes the mitotic spindle. It also interacts with nuclear histone acetyltransferases, promoting their positive effect on transcription. Human TACC3 is 838 amino acids (aa) in length and contains one poly-Serine region (aa 155‑160) and a TACC coiled-coil domain (aa 637‑837). There is one potential splice variant that shows a Lys substitution for aa 102‑462. Over amino acids 689‑838, human TACC3 shares 79% aa identity with mouse TACC3.

Long Name

Transforming Acidic Coiled-coil-containing Protein 3

Entrez Gene IDs

10460 (Human); 21335 (Mouse); 360962 (Rat)

Alternate Names

ERIC-1; ERIC1ERIC-1; MGC117382; MGC133242; TACC3; transforming acidic coiled-coil-containing protein 3; transforming, acidic coiled-coil containing protein 3