Human Trypsin 2/PRSS2 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB3586R Datasheet / COA / SDS

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FAB3586R-100UG

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Human Trypsin 2/PRSS2 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Trypsin 2/PRSS2 in direct ELISAs and Western blots. Does not cross‑react with recombinant human (rh) Trypsin 1 or rhTrypsin 3. Recognizes both the pro and mature forms of rhTrypsin 2.

Source

Monoclonal Mouse IgG1 Clone # 410322

Purification

Protein A or G purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Trypsin 2/PRSS2
Ala16-Ser247
Accession # P07478

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Trypsin 2/PRSS2

Human Trypsin 2, encoded by the PRSS2 gene, is also known as anionic Trypsin (1). Accounting for approximately 1/3 of the total trypsin content in the pancreatic juice, it is one of the trypsins produced in the pancreas. It consists of a signal peptide (residues 1‑15), a pro region (residues 16‑23), and a mature chain (residues 24‑247). Trypsin 2 is synthesized as a zymogen and secreted into the duodenal lumen, where it is activated by enteropeptidase (2). It plays a central role in digestion and activating other pro-enzymes. In human pancreatic diseases and chronic alcoholism, it is up-regulated (3).

Entrez Gene IDs

5645 (Human); 22072 (Mouse); 25052 (Rat)

Alternate Names

Anionic trypsinogen; EC 3.4.21; EC 3.4.21.4; MGC111183; MGC120174; MGC120175; protease serine 2 preproprotein; protease, serine, 2 (trypsin 2); protease, serine, 2, preproprotein; PRSS2; Serine protease 2; Tesp4; TRY2TRY8; TRY8; TRYP2; Trypsin 2; Trypsin II; trypsin-2; trypsinogen 2; Trypsinogen 20