IBMX

Tocris Bioscience | Catalog # 2845

PDE inhibitor (non-selective)
Tocris Bioscience

Key Product Details

Description

PDE inhibitor (non-selective)
View all Phosphodiesterase Inhibitors »

Product Description

IBMX is a phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). Facilitates differentiation of neural progenitor cells in vitro.

Product Specifications for IBMX

Molecular Weight

222.24

Formula

C10H14N4O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione

CAS Number

28822-58-4

PubChem ID

3758

InChI Key

APIXJSLKIYYUKG-UHFFFAOYSA-N

SMILES

O=C1C2=C(N=CN2)N(CC(C)C)C(N1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.67 75

Preparing Stock Solutions for IBMX

The following data is based on the product molecular weight 222.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 6.00 mL 30.00 mL 60.00 mL
3.75 mM 1.20 mL 6.00 mL 12.00 mL
7.5 mM 0.60 mL 3.00 mL 6.00 mL
37.5 mM 0.12 mL 0.60 mL 1.20 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 165 publications citing the usage of this product.

Product Documents for IBMX

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for IBMX

For research use only

Customer Reviews for IBMX (1)

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  • Rapid inhibition of PDE in acute brain slices
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: acute brain slice
    Verified Customer | Posted 01/04/2018
    Effect is observed within minutes.
    Exogenous application of IBMX on brain slices

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