ICG 001

Tocris Bioscience | Catalog # 4505

Inhibits TCF/β-catenin-mediated transcription
Tocris Bioscience

Key Product Details

Description

Inhibits TCF/β-catenin-mediated transcription
View all beta-Catenin Inhibitors »

Product Description

ICG 001 is an inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.

Product Specifications for ICG 001

Molecular Weight

548.63

Formula

C33H32N4O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

CAS Number

780757-88-2

PubChem ID

11238147

InChI Key

HQWTUOLCGKIECB-XZWHSSHBSA-N

SMILES

O=C1CCN(C(NCC5=CC=CC=C5)=O)[C@]2([H])N1[C@@H](CC6=CC=C(O)C=C6)C(N(CC3=C(C=CC=C4)C4=CC=C3)C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.86 100
Ethanol 27.43 50

Preparing Stock Solutions for ICG 001

The following data is based on the product molecular weight 548.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.82 mL 9.11 mL 18.23 mL
5 mM 0.36 mL 1.82 mL 3.65 mL
10 mM 0.18 mL 0.91 mL 1.82 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 31 publications citing the usage of this product.

Product Documents for ICG 001

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ICG 001

For research use only

Customer Reviews for ICG 001 (1)

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  • Good product.
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: BLaER1 DRP1 KO cell lines
    Verified Customer | Posted 07/07/2020
    BLaER1 DRP1 KO cell lines C12 and F11 and a corresponding wt-control cell line were treated with 10 µM ICG-001 or vehicle control for 2.5 h.
    ICG 001 4505

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