ICI 182,780

Tocris Bioscience | Catalog # 1047

Estrogen receptor antagonist
Tocris Bioscience

Key Product Details

Description

Estrogen receptor antagonist

Alternative Names

Fulvestrant
View all Estrogen and Related Receptor Antagonists »

Product Description

ICI 182,780 is a high affinity estrogen receptor antagonist (IC50 = 0.29 nM), devoid of any partial agonism both in vitro and in vivo. ICI 182,780 is a high affinity agonist at the membrane estrogen receptor GPER. ICI 182,780 inhibits MCF-7 human breast cancer cell growth in vitro and shows antitumor activity in mice models. ICI 182,780 penetrates the blood-brain-barrier and has neuronal functional effects in vivo.

Product Specifications for ICI 182,780

Molecular Weight

606.77

Formula

C32H47F5O3S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol

CAS Number

129453-61-8

PubChem ID

17756771

InChI Key

VWUXBMIQPBEWFH-LQKBAPIOSA-N

SMILES

OC1=CC=C2C(C[C@@H](CCCCCCCCCS(CCCC(F)(C(F)(F)F)F)=O)C3([H])[C@@]([H])2CC[C@@]4(C)[C@@](CC[C@@H]4O)3[H])=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 60.68 100
Ethanol 30.34 50

Preparing Stock Solutions for ICI 182,780

The following data is based on the product molecular weight 606.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.65 mL 8.24 mL 16.48 mL
5 mM 0.33 mL 1.65 mL 3.30 mL
10 mM 0.16 mL 0.82 mL 1.65 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 1140 publications citing the usage of this product.

Product Documents for ICI 182,780

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ICI 182,780

For research use only

Customer Reviews for ICI 182,780 (1)

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  • Used on human primary mammary epithelial cells
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Human Primary Mammary Epithelial Cells
    Verified Customer | Posted 04/18/2018
    This product was dissolved in ethanol and delivered to human primary mammary epithelial cells in vitro.

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