ICI 63197
Chemical Name: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
Purity: ≥99%
Biological Activity
Potent phosphodiesterase (PDE) 4 inhibitor (IC50 = 35 nM for inhibition of [3H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [3H]rolipram.
Kaulen et al.
Brain Res., 1989;503:229 -
Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors.
Wachtel
Neuropharmacology, 1983;22:267 -
Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram
Zhao et al.
J.Pharmacol.Exp.Ther., 2003;305:565
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