Human/mouse IL-28A (IFN-lambda 2), IL-28B (IFN-lambda 3), and human IL-29 (IFN-lambda 1) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid (aa) sequence identity) and type I IFN family (15 - 19% aa sequence identity). These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 R beta) and a novel IL-28 receptor alpha (IL-28 R alpha, also known as IFN-lambda R1). Mouse IL-28 shares 61%, 62%, and 52% aa identity with human IL-28A, IL-28B, and IL-29, respectively.
Recombinant Human IL-28B/IFN-lambda 3 His Protein
Novus Biologicals | Catalog # NBP2-52083
![SDS-PAGE: Recombinant Human IL-28B/IFN-lambda 3 His Protein [NBP2-52083]](https://resources.rndsystems.com/images/products/IL-28B-IFN-lambda-3-Recombinant-Protein-SDS-Page-NBP2-52083-img0001.jpg "SDS-PAGE: Recombinant Human IL-28B/IFN-lambda 3 His Protein [NBP2-52083]")
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Key Product Details
Source
Baculovirus
Tag
His
Applications
SDS-PAGE
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Product Specifications
Description
A recombinant protein with a C-Terminal His-tag and corresponding to the amino acids 22-196 of Human IL-28B/IFN-lambda 3
Source: Baculovirus
Amino Acid Sequence: VPVARLRGAL PDARGCHIAQ FKSLSPQELQ AFKRAKDALE ESLLLKDCKC RSRLFPRTWD LRQLQVRERP VALEAELALT LKVLEATADT DPALGDVLDQ PLHTLHHILS QLRACIQPQP TAGPRTRGRL HHWLHRLQEA PKKESPGCLE ASVTFNLFRL LTRDLNCVAS GDLCVHHHHH H
Purity
>85%, by SDS-PAGE
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Predicted Molecular Mass
20.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Protein / Peptide Type
Recombinant Protein
Scientific Data Images for Recombinant Human IL-28B/IFN-lambda 3 His Protein
SDS-PAGE: Recombinant Human IL-28B/IFN-lambda 3 His Protein [NBP2-52083]
SDS-Page: Recombinant Human IL-28B/IFN-lambda 3 Protein [NBP2-52083] - 15% SDS Page (3 ug)Formulation, Preparation, and Storage
NBP2-52083
| Formulation | PBS (pH 7.4), 20% glycerol, 1 mM EDTA, 0.1 mM PMSF |
| Preservative | No Preservative |
| Concentration | 0.25 mg/ml |
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Background: IL-28B/IFN-lambda 3
Long Name
Interleukin 28B
Alternate Names
IFN-lambda 3
Gene Symbol
IFNL3
Additional IL-28B/IFN-lambda 3 Products
Product Documents for Recombinant Human IL-28B/IFN-lambda 3 His Protein
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Recombinant Human IL-28B/IFN-lambda 3 His Protein
This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.
Related Research Areas
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Associated Pathways
