IMD 0354

Tocris Bioscience | Catalog # 2611

Inhibitor of IKKβ; also exhibits antibacterial activity
Tocris Bioscience

Key Product Details

Description

Inhibitor of IKKβ; also exhibits antibacterial activity
View all IkB Kinase Inhibitors »

Product Description

IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G0/G1 cell cycle arrest and apoptosis in HMC-1 and breast cancer cells. Antagonist at P2X1, P2X4 and P2X7 receptors (IC50 values are 19, 156 and 175 nM respectively). Inhibits platelet aggregation induced by collagen in vitro. Exhibits potent antibacterial activity against MRSA in C. elegans model (MIC = 0.06 μg/mL). Selective aquaporin 4 inhibitor (IC50 values are 210 nM, 390 nM and 420 nM at rat, mouse and human receptors, respectively).

Product Specifications for IMD 0354

Molecular Weight

383.67

Formula

C15H8ClF6NO2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide

CAS Number

978-62-1

PubChem ID

5081913

InChI Key

CHILCFMQWMQVAL-UHFFFAOYSA-N

SMILES

OC1=C(C=C(Cl)C=C1)C(=O)NC1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.36 100
Ethanol 38.36 100

Preparing Stock Solutions for IMD 0354

The following data is based on the product molecular weight 383.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.03 mL 26.06 mL
5 mM 0.52 mL 2.61 mL 5.21 mL
10 mM 0.26 mL 1.30 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 25 publications citing the usage of this product.

Product Documents for IMD 0354

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for IMD 0354

For research use only

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  • IMD 0354 ameliorates LPS-induced TNFa production
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Macrophages
    Verified Customer | Posted 12/11/2018
    RAW macrophages were incubated with 5 μM IMD 0354 for 30 min prior to addition of 200 ng/ml LPS for 8 h to follow TNFa mRNA expression. LPS elevated TNFa mRNA levels that was significantly inhibited by pretreatment of cells with IMD 0354.
    IMD 0354 2611

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