INCA Antibody - Azide and BSA Free

Novus Biologicals | Catalog # H00440068-B01P

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Mouse IgG

Format

Azide and BSA Free
View all INCA Primary Antibodies »

Product Specifications

Immunogen

INCA (NP_001007233.1, 1 a.a. - 110 a.a.) full-length human protein. MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDSVIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS

Specificity

INCA - inhibitory caspase recruitment domain (CARD) protein,

Clonality

Polyclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for INCA Antibody - Azide and BSA Free

Western Blot: INCA Antibody [H00440068-B01P]

Western Blot: INCA Antibody [H00440068-B01P]

Western Blot: INCA Antibody [H00440068-B01P] - Analysis of CARD17 expression in transfected 293T cell line by CARD17 polyclonal antibody. Lane 1: INCA transfected lysate(12.1 KDa). Lane 2: Non-transfected lysate.

Applications for INCA Antibody - Azide and BSA Free

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: INCA

INCA, also known as CAR17 or Caspase recruitment domain-containing protein 17, is a 110 amino acid protein that is 12 kDa; cytoplasm located; regulates procaspase-1/CASP1 activation involved in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation; and acts as an inhibitor of the release of IL1B in response to LPS in monocytes. Current research is being pursued on this protein involvement in several diseases and disorders including cancer, familial mediterranean fever, shigellosis, cowpox, neurodegenerative disease, vascular disease, mevalonic aciduria, tularemia, dermatitis, lung disease, legionnaires' disease, and arthritis. This protein has been linked to the proteolysis and regulation of apoptotic process pathways where it interacts with CASP1, CARD16, and CARD18 proteins.

Alternate Names

caspase recruitment domain family, member 17, caspase recruitment domain-containing protein 17, Caspase-1 inhibitor INCA, INCAInhibitory CARD, inhibitory caspase recruitment domain (CARD) protein, Inhibitory caspase recruitment domain protein

Entrez Gene IDs

440068 (Human)

Gene Symbol

CARD17P

UniProt

NP_001007233.1 (Human)

Additional INCA Products

Product Documents for INCA Antibody - Azide and BSA Free

Certificate of Analysis

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Product Specific Notices for INCA Antibody - Azide and BSA Free

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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