Iressa

Key Product Details

Product Description

Iressa is an orally active, selective inhibitor of EGFR tyrosine kinase (IC₅₀ = 23 - 79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice bearing a range of human xenografts. Also inhibits growth of brain metastases in mouse model of non-small cell lung cancer.

View information regarding the usage of Iressa for non-clinical studies.

Licensing Information

Sold for research purposes only under agreement from AstraZeneca

Product Specifications for Iressa

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Iressa

The following data is based on the product molecular weight 446.90.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.19 mL	22.38 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 335 publications citing the usage of this product.

• Tan Tyrosine kinase inhibitors show different anti-brain metastases efficacy in NSCLC: A direct comparative analysis of icotinib, gefitinib, and erlo. in a nude mouse model. Oncotarget. 2017 PMID: 29228726
• Baselga ZD1839 ('Iressa'), as an anticancer agent. Drugs 2000 PMID: 11129170
• McKillop Tumor penetration of gefi. (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor. Mol.Cancer Ther. 2005 PMID: 15827338
• Ciardiello Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin.Cancer Res. 2000 PMID: 10815932

Product Documents for Iressa