ITH 12575

Key Product Details

Product Description

ITH 12575 is a mitochondrial Na⁺/Ca²⁺ exchange (mNCX) inhibitor. Reduces Ca²⁺ efflux from the mitochondria to the cytosol in HeLa cells (EC₅₀ = 0.69 μM). Protects against glutamate-induced excitotoxitiy in rat hippocampal slices and oligomycin A/rotenone induced oxidative stress in neuroblastoma cells in vitro.

Product Specifications for ITH 12575

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ITH 12575

The following data is based on the product molecular weight 331.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.07 mL	30.13 mL
5 mM	0.60 mL	3.01 mL	6.03 mL
10 mM	0.30 mL	1.51 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Moreno-Ortega Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca²⁺ entry through CALHM1. Neuropharmacology 2015 PMID: 25908402
• Martínez-Sanz Benzothiazepine CGP37157 analogues exert cytoprotection in various in vitro models of neurodegeneration. ACS Chem.Neurosci. 2015 PMID: 26192029

Product Documents for ITH 12575