Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Janelia Fluor 669

Antibody Source

Polyclonal Sheep IgG
View all ITM2C Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human ITM2C
Ala86-Val267
Accession # Q9NQX7

Specificity

Detects human ITM2C in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) ITM2A and rhITM2B is observed.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications for ITM2C Antibody [Janelia Fluor® 669]

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: ITM2C

ITM2C also known as Integral membrane protein 2C, has 3 isoforms, an isoform 1that is 267 amino acid and 30 kDa, an isoform 2 that is 220 amino acid and 25 kDa, and an isoform 3 that is 230 amino acid and 26 kDa; most commonly found in the brain tissue; acts as negative regulator of beta amyloid peptide production, may inhibit the processing of APP by blocking its access to alpha- and beta-secretase, appears to be a poor gamma-secretase cleavage inhibitor, and may play a role in TNF-induced cell death and neuronal differentiation. Studies are being performed on the relationship of this protein to anemia of prematurity, cerebritis, anemia, dementia, influenza, gastric cancer, and neuronitis. The protein has been shown to interact with BACE1, APP, STMN2, STT3A, RNF7, and FURIN proteins in negative regulation of neuron projection development, induction of programmed cell death, and neuron differentiation pathways.

Long Name

Integral Membrane Protein 2C

Alternate Names

BRI3, BRICD2C, Cerebral protein 14

Gene Symbol

ITM2C

Additional ITM2C Products

Product Documents for ITM2C Antibody [Janelia Fluor® 669]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for ITM2C Antibody [Janelia Fluor® 669]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Cancer Biomarkers

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