ITX 3

Key Product Details

Product Description

ITX 3 is a selective inhibitor of TrioN RhoGEF activity. Inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro.

Product Specifications for ITX 3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ITX 3

The following data is based on the product molecular weight 371.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	53.84 mL	269.22 mL	538.43 mL
0.25 mM	10.77 mL	53.84 mL	107.69 mL
0.5 mM	5.38 mL	26.92 mL	53.84 mL
2.5 mM	1.08 mL	5.38 mL	10.77 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bouquier A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem.Biol. 2009 PMID: 19549603

Product Documents for ITX 3