IU1-47

Key Product Details

Product Description

IU1-47 is a potent USP14 inhibitor (IC₅₀ = 60 nM). Demonstrates >30-fold selectivity for USP14 over USP5 (IsoT). Enhances degradation of proteasome substrates in vitro. Increases degradation of wild type and pathological tau in MEFs, primary neuronal cultures and human iPSC derived neurons.

Product Specifications for IU1-47

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for IU1-47

The following data is based on the product molecular weight 330.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.23 mL	151.13 mL	302.25 mL
0.5 mM	6.05 mL	30.23 mL	60.45 mL
1 mM	3.02 mL	15.11 mL	30.23 mL
5 mM	0.60 mL	3.02 mL	6.05 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Boselli An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J.Biol.Chem. 2017 PMID: 28972160

Product Documents for IU1-47