IU1
Discontinued Product
Chemical Name: 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone
Purity: ≥98%
Biological Activity
Selective inhibitor of Usp14; inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 μM). Stimulates proteasome activity and substrate degradation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Coaggregation of RNA-Binding Proteins in a Model of TDP-43 Proteinopathy with Selective RGG Motif Methylation and a Role for RRM1 Ubiquitination.
Dammer EB, Fallini C, Gozal YM
PLoS ONE, 2012;7(6):e38658. -
Enhancement of proteasome activity by a small-molecule inhibitor of USP14.
Lee et al.
Nature, 2010;467:179 -
Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes.
Lee et al.
Mol.Cell.Proteomics, 2010;10:R110
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