Ivermectin

Tocris Bioscience | Catalog # 1260

Positive allosteric modulator of α7 nAChRs; also positive allosteric modulator of P2X4 receptors
Tocris Bioscience
Discontinued Product
1260 has been discontinued. View all Nicotinic (a7) Receptor Modulators products.

Key Product Details

Description

Positive allosteric modulator of α7 nAChRs; also positive allosteric modulator of P2X4 receptors
View all Nicotinic (a7) Receptor Modulators »

Product Description

Ivermectin is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic and antiviral. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM). Inhibits replication of SARS-CoV-2 in vitro (IC50 ~ 2μM).

This product is composed of both Ivermectin B1a (>90%) and Ivermectin B1b.

Product Specifications for Ivermectin

Molecular Weight

875.10

Formula

C48H74O14 (B1a form)

Storage

Desiccate at +4°C

Purity

≥96% (HPLC)

Chemical Name

22,23-Dihydroavermectin B1

CAS Number

70288-86-7

PubChem ID

6321424

InChI Key

AZSNMRSAGSSBNP-XPNPUAGNSA-N

SMILES

O[C@H]1[C@H](C)O[C@](O[C@H]2[C@@H](O[C@](O[C@H](/C(C)=C/C[C@@]4([H])O[C@@]7(CC[C@H](C)[C@@]([H])([C@]([H])(C)C)O7)C[C@@H]6C4)[C@@H](C)/C=C/C=C3/[C@]5(O)[C@]([C@H](O)C(C)=CC5C(O6)=O)([H])OC3)([H])C[C@@H]2OC)C)([H])C[C@@H]1OC.O[C@H]8[C@H](C)O[C@](O[C@H]9[C@@H](O[C@](O[C@H](/C(C)=C/C[C@@]%11([H])O[C@@]%14(CC[C@H](C)[C@@]([H])([C@]([H])(C)CC)O%14)C[C@@H]%13C%11)[C@@H](C)/C=C/C=C%10/[C@]%12(O)[C@]([C@H](O)C(C)=CC%12C(O%13)=O)([H])OC%10)([H])C[C@@H]9OC)C)([H])C[C@@H]8OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50

Preparing Stock Solutions for Ivermectin

The following data is based on the product molecular weight 875.10.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.29 mL 11.43 mL 22.85 mL
2.5 mM 0.46 mL 2.29 mL 4.57 mL
5 mM 0.23 mL 1.14 mL 2.29 mL
25 mM 0.05 mL 0.23 mL 0.46 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 39 publications citing the usage of this product.

Product Documents for Ivermectin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ivermectin

For research use only

Customer Reviews for Ivermectin (1)

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  • P2X4 potentiation
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 10/02/2018
    Potentiates P2X4 responses in cultured microglia

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