IWP 4

Tocris Bioscience | Catalog # 5214

Potent inhibitor of Wnt/β-catenin signaling
Tocris Bioscience

Key Product Details

Description

Potent inhibitor of Wnt/β-catenin signaling
View all beta-Catenin Inhibitors »

Product Description

IWP 4 is a potent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.

Product Specifications for IWP 4

Molecular Weight

496.62

Formula

C23H20N4O3S3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

CAS Number

686772-17-8

PubChem ID

2155264

InChI Key

RHUJMHOIQBDFQR-UHFFFAOYSA-N

SMILES

O=C1C3=C(CCS3)N=C(SCC(NC4=NC(C=CC(C)=C5)=C5S4)=O)N1C2=C(OC)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.5 1

Preparing Stock Solutions for IWP 4

The following data is based on the product molecular weight 496.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.01 mM 201.36 mL 1,006.81 mL 2,013.61 mL
0.05 mM 40.27 mL 201.36 mL 402.72 mL
0.1 mM 20.14 mL 100.68 mL 201.36 mL
0.5 mM 4.03 mL 20.14 mL 40.27 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 53 publications citing the usage of this product.

Product Documents for IWP 4

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for IWP 4

For research use only

Customer Reviews for IWP 4 (1)

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  • would use again
    Name: Anonymous
    Verified Customer | Posted 05/10/2018
    colleague used for an experiment

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