J 147

Key Product Details

Product Description

J 147 is a potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC₅₀ = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.

Licensing Information

Sold for research use only under license from the Salk Institute for Biological Studies

Product Specifications for J 147

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for J 147

The following data is based on the product molecular weight 350.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.27 mL	28.54 mL
5 mM	0.57 mL	2.85 mL	5.71 mL
10 mM	0.29 mL	1.43 mL	2.85 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Prior The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimer's.Res.Ther. 2013 PMID: 23673233
• Chiruta Metabolism of a potent neuroprotective hydrazide. Bioorg.Med.Chem. 2013 PMID: 23582448
• Chen A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One 2011 PMID: 22194796

Product Documents for J 147