J 2156

Key Product Details

Product Description

J 2156 is a high affinity human somatostatin receptor 4 (sst₄) agonist (K_i = 1.2 nM). Displays >400-fold selectivity for human sst₄ over other human sst receptor subtypes. Exhibits 2 to 3-fold more potent agonism in vitro than endogenous ligands somatostatin-14 (Cat. No. 1157) and somatostatin-28 (Cat. No. 1165). Reduces inflammatory airway hyperresponsiveness in acute and chronic airway inflammation models in mice. Exhibits anxiolytic effects in elevated plus maze test in mice.

Product Specifications for J 2156

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for J 2156

The following data is based on the product molecular weight 582.60.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.72 mL	8.58 mL	17.16 mL
5 mM	0.34 mL	1.72 mL	3.43 mL
10 mM	0.17 mL	0.86 mL	1.72 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Elekes Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse. Eur.J.Pharmacol. 2008 PMID: 17961545
• Scheich Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models. Neuropharmacology. 2016 PMID: 26387439
• Engström Superagonism at the human somatostatin receptor subtype 4. J.Pharmacol.Exp.Ther. 2005 PMID: 15333679

Product Documents for J 2156