Chemical Name: N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine
Biological ActivityJNJ 10198409 is a potent platelet-derived growth factor receptor (PDGFR) inhibitor (IC50 values are 4.2 and 45 nM for PDGFRβ and PDGFRα, respectively). Also inhibits c-Abl, Lck, c-Src and Fyn kinases (IC50 values are 22, 100, 185 and 378 nM respectively). Displays antiproliferative activity in multiple tumor cell lines. Accelerates down regulation of fibroblast genes in transdifferentiation of human fibroblasts into functional cardiomyocytes, within 9C cocktail.
For more information about how JNJ 10198409 may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Conversion of human fibroblasts into functional cardiomyocytes by small molecules.
Cao et al.
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
Ho et al.
Citations for JNJ 10198409
The citations listed below are publications that use Tocris products. Selected citations for JNJ 10198409 include:
8 Citations: Showing 1 - 8
Anaplastic Lymphoma Kinase Regulates Internalization of the Dopamine D2 Receptor.
Authors: Donghong Et al.
Mol Pharmacol 2020;97:123-131
Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth.
Authors: Ulrich Et al.
Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway.
Authors: Stephen H Et al.
PLoS One 2016;11:e0161445
Conventional protein kinase C isoforms differentially regulate ADP- and thrombin-evoked Ca2+ signalling in human platelets.
Authors: Stewart O Et al.
Cell Calcium 2015;58:577-88
Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathway.
Authors: Anisur Et al.
Dev Cell 2014;31:747-60
Protein kinase D promotes airway epithelial barrier dysfunction and permeability through down-regulation of claudin-1.
Authors: Q Jane Et al.
J Biol Chem 2013;288:37343-54
Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein.
Authors: Zhihui Et al.
J Biol Chem 2011;286:39450-6
Protein kinase C activity modulates dendritic differentiation of rat Purkinje cells in cerebellar slice cultures.
Authors: F Et al.
Eur J Neurosci 2000;12:1993-2005
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