JP-2-196

Tocris Bioscience | Catalog # 8046

RNF126 chemical handle
Tocris Bioscience

Key Product Details

Description

RNF126 chemical handle
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Product Description

JP-2-196 is a covalent RNF126 chemical handle that binds to several other RING E3 ubiquitin ligases including RNF14, RNF40, RNF219, MID2, and LRSAM. By facilitating E3 ligase recruitment, JP-2-196 induces proteasomal degradation of diverse target proteins. It serves as a modular scaffold for the design and synthesis of molecular glue degraders.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for JP-2-196

Molecular Weight

310.78

Formula

C15H18N2O3.HCl

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

1-(4-Methoxyphenyl)-4-(1-piperazinyl)-2-butene-1,4-dione hydrochloride

InChI Key

KITOUXXMDYKXJY-UHDJGPCESA-N

SMILES

O=C(C1=CC=C(C=C1)OC)/C=C/C(N2CCNCC2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for JP-2-196

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for JP-2-196

For research use only

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