JT010

Tocris Bioscience | Catalog # 6269

Potent and selective TRPA1 channel activator
Tocris Bioscience

Key Product Details

Description

Potent and selective TRPA1 channel activator
View all TRPA1 Activators »

Product Description

JT010 is a potent and selective TRPA1 channel activator (EC50 = 0.65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM).

Product Specifications for JT010

Molecular Weight

354.85

Formula

C16H19ClN2O3S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide

CAS Number

917562-33-5

PubChem ID

18524489

InChI Key

KZMAWJRXKGLWGS-UHFFFAOYSA-N

SMILES

O=C(N(CCCOC)C1=NC(C2=CC=C(OC)C=C2)=CS1)CCl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.48 100
Ethanol 17.74 50

Preparing Stock Solutions for JT010

The following data is based on the product molecular weight 354.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.09 mL 28.18 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for JT010

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for JT010

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for JT010 (1)

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  • An excellent TRPA1 channel activator
    Name: Zili Xie
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: HEK293
    Verified Customer | Posted 02/03/2019
    300 nM JT010 evoked Calcium responses in HEK293 cells transfected with recombinant TRPA1.
    JT010 6269

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