JTE 013

Key Product Details

Product Description

JTE 013 is a sphingosine-1-phosphate (S1P) receptor antagonist, highly selective for S1P₂ (EDG-5). Inhibits S1P binding to human S1P₂ receptors with an IC₅₀ value of 17.6 nM. At concentrations up to 10 μM, displays 4.2% inhibition of S1P₃ and does not antagonize S1P₁. Enhances S1P-induced angiogenesis in vivo.

Product Specifications for JTE 013

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for JTE 013

The following data is based on the product molecular weight 408.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.25 mL	24.49 mL
5 mM	0.49 mL	2.45 mL	4.90 mL
10 mM	0.24 mL	1.22 mL	2.45 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 95 publications citing the usage of this product.

• Parrill Sphingosine 1-phosphate and lysophosphatidic acid receptors: agonist and antagonist binding and progress toward development of receptor-specific ligands. Semin.Cell.Dev.Biol. 2004 PMID: 15271292
• Inoki Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor. Biochem.Biophys.Res.Comm.
• Ohmori Spingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. Cardiovasc.Res. 2003 PMID: 12667959

Product Documents for JTE 013