Kartogenin

Tocris Bioscience | Catalog # 4513

Potently induces chondrogenesis in MSCs
Tocris Bioscience
Discontinued Product
4513 has been discontinued. View all Compounds for Stem Cell Differentiation products.

Key Product Details

Description

Potently induces chondrogenesis in MSCs
View all Compounds for Stem Cell Differentiation »

Product Description

Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Reduces disease severity in a mouse model of osteoarthritis; displays protective effects against osteoarthritic stimuli in mature chondrocytes in vitro.

Product Specifications for Kartogenin

Molecular Weight

317.34

Formula

C20H15NO3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[((1,1'-Biphenyl)-4-ylamino)carbonyl]benzoic acid

CAS Number

4727-31-5

PubChem ID

2826191

InChI Key

SLUINPGXGFUMLL-UHFFFAOYSA-N

SMILES

O=C(NC2=CC=C(C3=CC=CC=C3)C=C2)C1=CC=CC=C1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.73 100
Ethanol 15.87 50

Preparing Stock Solutions for Kartogenin

The following data is based on the product molecular weight 317.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.76 mL 31.51 mL
5 mM 0.63 mL 3.15 mL 6.30 mL
10 mM 0.32 mL 1.58 mL 3.15 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for Kartogenin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Kartogenin

For research use only

Customer Reviews for Kartogenin (1)

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  • Chondrogenic differentiation of human bone marrow stromal cells
    Name: Nicola Foster
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 08/28/2020
    Added to culture medium on days 1-3 at 10 µM to induced chondrogenic differentiation in an immortalized hBMSC cell line. After 7 days there was increased sulfated GAG production compared to basic controls and increased DNA yield compared to cells cultured in traditional chondrogenic differentiation medium.
    Kartogenin 4513

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