kb NB 142-70

Key Product Details

Product Description

kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC₅₀ values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro; displays prominent cytotoxic and anti-proliferative effects.

Product Specifications for kb NB 142-70

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for kb NB 142-70

The following data is based on the product molecular weight 251.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.98 mL	19.89 mL	39.79 mL
5 mM	0.80 mL	3.98 mL	7.96 mL
10 mM	0.40 mL	1.99 mL	3.98 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Bravo-Altamirano Synthesis and structure-activity relationships of benzothienothiazepinone inhibitors of protein kinase D. ACS Med.Chem.Lett. 2011 PMID: 21617763
• Ni PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. PLoS One 2013 PMID: 24039875
• LaValle Novel protein kinase D inhibitors cause potent arrest in cancer cell growth and motility. BMC Chemical Biology 2010 PMID: 20444281

Product Documents for kb NB 142-70