KB SRC 4

Tocris Bioscience | Catalog # 4660

Potent and selective c-Src inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective c-Src inhibitor
View all Src Family Kinase Inhibitors »

Product Description

KB SRC 4 is a potent and selective c-Src inhibitor (Ki = 44 nM); does not inhibit c-Abl at concentrations up to 125 μM. Selective between Src family members (Kd values are 86, 160, 240, 720, 3200, 4400, and >40,000 nM for c-Src, Lck, Fgr, Yes, Lyn, Hck and Fyn respectively). Significantly inhibits cell growth in 4T1 mammary carcinoma tumor cells.

Product Specifications for KB SRC 4

Molecular Weight

555.03

Formula

C32H23ClN8

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[3-[1-([1,1'-Biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

CAS Number

1380088-03-8

PubChem ID

73349077

InChI Key

UHIZYQVRKSWIFO-UHFFFAOYSA-N

SMILES

NC1=C2C(N(C4=CC=CC(C5=CN=NN5CC6=CC(C7=CC=CC=C7)=CC=C6)=C4)N=C2C3=CC=C(Cl)C=C3)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.1 20

Preparing Stock Solutions for KB SRC 4

The following data is based on the product molecular weight 555.03.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.01 mL 45.04 mL 90.09 mL
1 mM 1.80 mL 9.01 mL 18.02 mL
2 mM 0.90 mL 4.50 mL 9.01 mL
10 mM 0.18 mL 0.90 mL 1.80 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for KB SRC 4

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for KB SRC 4

For research use only

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